Oncogene

FIGURE 1

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Genome-wide array-based CGH for mantle cell lymphoma: identification of homozygous deletions of the proapoptotic gene BIM

Hiroyuki Tagawa, Sivasundaram Karnan, Ritsuro Suzuki, Keitaro Matsuo, Xiaohua Zhang, Akinobu Ota, Yasuo Morishima, Shigeo Nakamura and Masao Seto

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Figure 1.

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Representative genomic profiles for individual tumors. Whole genomic profiles are shown for a representative patient sample (a) and the SP-53 cell line (b). Log2 ratios were plotted for all clones on the basis of chromosome position, with the vertical lines showing separation of chromosomes. The BACs and PACs are ordered according to their position in the genome from the 1p telomere on the left to the Xq telomere on the right. (a) Regions of copy number gain: 5p, 7p21.3, 17q21.31−q24.3 and X. Regions of copy number loss: 1p32, 2p11.2, 2q13, 8p12−p23.3, 8q12.3−q13.1, 9p24.3−q31.2, 11q22.3−q23.2, 13q14.3−q21.1 and 15. (b) Regions of copy number gain: 7p11.2−p22.3. Regions of copy number loss: 1p36.23−p36.32, 1p13.3−p31.2, 1q13.2−q44, 2p11.2−q14.3, 4p15.1−p16.1, 6q14.1−q21, 6q23.2−q26, 7q22.1−q32.3, 9p21.3−p22.1, 11q22.3−q23.2, 18q22.1 and 20q13.13−q13.2

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