Review
Oncogene (2005) 24, 7394–7400. doi:10.1038/sj.onc.1209089
Class reunion: PTEN joins the nuclear crew
Zenglin Lian1 and Antonio Di Cristofano1
1Human Genetics Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
Correspondence: A Di Cristofano, E-mail: antonio.dicristofano@fccc.edu
Abstract
Several recent reports have brought conclusive evidence that the tumor suppressor PTEN, once considered a strictly cytoplasmic protein, shuttles to the nuclear compartment, where it joins a variety of components of the same pathway it regulates in the cytoplasm, among which PI3K, PDK1 and AKT. In this review, we focus on the growing supporting evidence for an important physiological role of this nuclear pathway and on the role that alteration of this novel regulatory circuit may play during cell transformation.
Keywords:
PTEN, AKT, nucleus
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