Abstract
The formation of multiprotein complexes is l’ordre du jour in regulatory pathways. In this issue of Oncogene, Reale et al. report the formation of a particularly sophisticated complex of two important regulatory enzymes, DNMT1 (DNA methyltransferase-1) and PARP-1 (poly(ADP-ribose)polymerase-1). The former evolved with a specific sequence motif binding the enzymatic product of the latter. The product, poly(ADP-ribose), bonds the two partners into a heterodimeric complex and, as a consequence, the catalytic function of DNMT1 is silenced. Thus, PARP-1 becomes a conditional negative regulator of DNMT1. In a larger perspective, Reale et al. highlight the potential role of PARP-1 as a co-regulator of DNA methylation leading to epigenetic reprogramming of cancer cells.
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Althaus, F. Poly(ADP-ribose): a co-regulator of DNA methylation?. Oncogene 24, 11–12 (2005). https://doi.org/10.1038/sj.onc.1208382
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DOI: https://doi.org/10.1038/sj.onc.1208382
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