Oncogene

FIGURE 5

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Loss of CCAAT/enhancer binding protein delta promotes chromosomal instability

A-Mei Huang, Cristina Montagna, Shikha Sharan, Yajun Ni, Thomas Ried and Esta Sterneck

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Figure 5.

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SKY analysis of primary MEF derived from Cebpd-deficient embryos. (a) Classification colors and (b) DAPI image for a metaphase from mutant MEF (KO#1 of Table 1) demonstrating significant chromosomal instability. The arrow indicates a complex rearrangement. Arrowheads point to acentric fragments, dicentric chromosomes and Robertsonian translocations. (c) Examples of rearrangements seen in different metaphases derived from KO#1 and KO#2 MEF (see Table 1)

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