FIGURE 2
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-parvin inhibits integrin-linked kinase signaling and is downregulated in breast cancer
Perry S Mongroo, Cameron N Johnstone, Izabela Naruszewicz, Chungyee Leung-Hagesteijn, Raphael K Sung, Leanne Carnio, Anil K Rustgi and Gregory E Hannigan
BACK TO ARTICLEFigure 2.
ParvB mRNA transcipt levels are reduced in human breast tumors and cell lines. (a) Q-RT–PCR of ParvB expression in paired human breast tumors and the adjacent normal mammary gland (see Materials and methods). Error bars indicate standard deviation for triplicate determinations. Pairwise t-test across nine samples indicated significant reduction of ParvB transcript levels (P=0.005). (b) RT–PCR analysis of ParvB expression was performed for the human mammary gland and breast cell lines, using primers spanning the terminal four exons (10–13) on the 3'-end of the PARVB cDNA (pan-ParvB). All RT minus control samples revealed no PCR product. L1 is normal liver. M1 is liver metastasis
