TABLE 1
FROM:
Budesonide exerts its chemopreventive efficacy during mouse lung tumorigenesis by modulating gene expressions
Ruisheng Yao, Yian Wang, William J Lemon, Ronald A Lubet and Ming You
BACK TO ARTICLETable 1. Chemopreventive effects of budesonide on B[a]P-induced lung tumorigenesis in A/J mice
| Carcinogen | Chemo preventive agent | Tumor incidence | Tumor no./mouse | Decrease in multiplicity (%) | Total tumor vol./mouse (mm3) | Decrease in vol. (%) |
|---|---|---|---|---|---|---|
| Vehicle | Vehicle | 5/16 (31.3%) | 0.31 0.47 | 1.243.27 | ||
| B[a]P | Vehicle | 12/12 (100%) | 11.633.20 | 24.0915.7 | ||
| B[a]P | Bud | 17/19 (89.5%) | 3.472.26b
| 69.8 | 1.511.58b
| 93.8 |
a Approximately equal numbers of males and females were used, with no significant difference in tumor multiplicity between the sexes. At 6 weeks of age, mice in groups 2 and 3 were given single i.p. injection of B[a]P (100 mg/kg in tricaprylin). Mice in group 3 were fed with budesonide (1.5 mg/kg) diet 2 weeks prior the B[a]P treatment and continue for the entire experiment.
b P<0.01, tumor multiplicity or volume in budesonide group was significantly different from that from B[a]P treatment group. Bud, budesonide
