Oncogene

FIGURE 1

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Mutation of GATA3 in human breast tumors

Jerry Usary, Victor Llaca, Gamze Karaca, Shafaq Presswala, Mehmet Karaca, Xiaping He, Anita Langerød, Rolf Kåresen, Daniel S Oh, Lynn G Dressler, Per E Lønning, Robert L Strausberg, Stephen Chanock, Anne-Lise Børresen-Dale and Charles M Perou

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Figure 1.

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Human GATA3 gene and protein overview. (a) Exon structure of GATA3 showing the functional domains and region of mutations. (b) GATA3 protein sequence surrounding the second zinc-finger and the location of variants identified in this study, and in three different HDR kindred studies. (c) Diagrammatic representation of the mis-splicing event that occurred in tumor BR99-0207. (d) Amino-acid identity plot of similar vertebrate GATA proteins and the locations of the breast tumor GATA3 variants; identical residues are identified by black boxes

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