Oncogene

FIGURE 4

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Distinct roles for p53, p27Kip1, and p21Cip1 during tumor development

Jeannette Philipp-Staheli, Kyung-Hoon Kim, Denny Liggitt, Kay E Gurley, Gary Longton and Christopher J Kemp

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Figure 4.

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Reduced p27 expression in tumors. (a) H&E stained section of p53-/- lymphoma. The arrow points to the mitotic figure. (b) Immunostaining for p27 in a p53-/- lymphoma. Arrows point to the tumor cell negative for nuclear p27 staining. Note the occasional p27-positive cell within the tumor. (c) Immunostaining for p27 of normal p53-/- thymus shows strong nuclear staining, especially in the medulla. (d) H&E stained section of p53-/- sarcoma. (e) Immunostaining for p27 in p53-/- sarcoma. The arrow points to the tumor cell negative for nuclear p27 staining

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