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Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks

Oncogene volume 23, pages 2934–2949 (2004)Cite this article

Abstract

Intrinsic (innate) and acquired (adaptive) resistance to chemotherapy critically limits the outcome of cancer treatments. For many years, it was assumed that the interaction of a drug with its molecular target would yield a lethal lesion, and that determinants of intrinsic drug resistance should therefore be sought either at the target level (quantitative changes or/and mutations) or upstream of this interaction, in drug metabolism or drug transport mechanisms. It is now apparent that independent of the factors above, cellular responses to a molecular lesion can determine the outcome of therapy. This review will focus on programmed cell death (apoptosis) and on survival pathways (Bcl-2, Apaf-1, AKT, NF-κB) involved in multidrug resistance. We will present our molecular interaction mapping conventions to summarize the AKT and IκB/NF-κB networks. They complement the p53, Chk2 and c-Abl maps published recently. We will also introduce the ‘permissive apoptosis-resistance’ model for the selection of multidrug-resistant cells.

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Authors and Affiliations

  1. Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, NIH, DHHS, Bethesda, 20892, MD, USA

    Yves Pommier, Olivier Sordet, Smitha Antony & Kurt W Kohn

  2. Cancer Research United Kingdom, Western General Hospital, Edinburgh, EH4 2XU, UK

    Richard L Hayward

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  1. Yves Pommier
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  2. Olivier Sordet
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  3. Smitha Antony
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Correspondence to Yves Pommier.

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Pommier, Y., Sordet, O., Antony, S. et al. Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks. Oncogene 23, 2934–2949 (2004). https://doi.org/10.1038/sj.onc.1207515

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