Oncogene

FIGURE 5

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alpha6bold italic beta1 integrin induces proteasome-mediated cleavage of erbB2 in breast cancer cells

Hajime Shimizu, Takashi Seiki, Makoto Asada, Kentaro Yoshimatsu and Noriyuki Koyama

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Figure 5.

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Effects of heregulin beta1 and IGF-1 on growth of ErbB2/mock and ErbB2/beta4-Deltacyt cells. (a) Cells were cultured in suspension with (closed column) or without (open column) heregulin beta1. Relative cell number was quantified after 4 days of cultivation. (b) Cells were cultured in suspension for a day, and stimulated with BSA (open column), heregulin beta1 (closed column) and IGF-1 (hatched column). Relative cell number was quantified at 3 days after stimulation

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