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PI3K/Akt and apoptosis: size matters

Oncogene volume 22, pages 8983–8998 (2003)Cite this article

Abstract

Recent research has examined Akt and Akt-related serine–threonine kinases in signaling cascades that regulate cell survival and are important in the pathogenesis of degenerative diseases and in cancer. We seek to recapitulate the research that has helped to define the current understanding of the role of the Akt pathway under normal and pathologic conditions, also in view of genetic models of Akt function. In particular, we will evaluate the mechanisms of Akt regulation and the role of Akt substrates in Akt-dependent biologic responses in the decisions of cell death and cell survival. Here, we hope to establish the mechanisms of apoptosis suppression by Akt kinase as a framework for a more general understanding of growth factor-dependent regulation of cell survival.

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Acknowledgements

TFF is supported by Career Development Award DAMD17-0-1-0214 and a scholarship from the Mary Kay Ash Charitable Foundation. We also acknowledge support from the German Scholarship Foundation for CPH. In addition, we value the editor's patience.

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  1. Department of Pharmacology, College of Physicians & Surgeons, Columbia University, 630 West 168th Street, New York, PH7-W318, 10032, NY, USA

    Thomas F Franke, Christoph P Hornik, Lisa Segev, Grigoriy A Shostak & Chizuru Sugimoto

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Franke, T., Hornik, C., Segev, L. et al. PI3K/Akt and apoptosis: size matters. Oncogene 22, 8983–8998 (2003). https://doi.org/10.1038/sj.onc.1207115

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