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Viruses and cancer: lessons from the human polyomavirus, JCV

Oncogene volume 22, pages 6517–6523 (2003)Cite this article

Abstract

The possible role of eucaryotic viruses in the development of cancer has been the subject of intense investigation during the past 50 years. Thus far, a strong link between some RNA and DNA viruses and various cancers in humans has been established and the transforming activity of several of the viruses in cell culture and their oncogenecity in experimental animals has been well documented. Perhaps, one of the most common themes among the oncogenic viruses rests in the ability of one or more of the viral proteins to deregulate pathways involved in the control of cell proliferation. For example, inactivation of tumor suppressors through their association with viral transforming proteins, and/or impairment of signal transduction pathways upon viral infection and expression of viral proteins are among the key biological events that can either trigger and/or contribute to the process of cancer. In recent years, more attention has been paid to human polyomaviruses, particularly JC virus (JCV), which infects greater than 80% of the human population, due to the ability of this virus to induce a fatal demyelinating disease in the brain, its presence in various tumors of central nervous system (CNS) and non-CNS origin, and the oncogenic potential of this virus in several laboratory animal models. Here, we will focus our attention on JCV and describe several pathways employed by the virus to contribute to and/or accelerate cancer development.

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References

  • Baserga R . (1999). Exp. Cell Res., 253, 1–6.

  • Berger JR and Concha M . (1995). J. Neurovirol., 1, 5–18.

  • Berger JR, Levy RM, Flomenhoft D and Dobbs M . (1998). Ann. Neural., 44, 341–349.

  • Bofill-Mas S, Formiga-Cruz M, Clemente-Casares P, Calafell F and Girones R . (2001). J. Virol., 75, 10290–10299.

  • Bollag B, Chuke W-F and Frisque RJ . (1989). J. Virol., 63, 863–872.

  • Bollag B, Prins C, Snyder EL and Frisque RJ . (2000). Virology, 274, 165–178.

  • Carswell S and Alwine JC . (1986). J. Virol., 60, 1055–1061.

  • Castaigne P, Rondot P, Escourolle R, Ribadeau Dumas J-L, Cathala F and Hauw J-J . (1974). Rev. Neurol. Paris, 130, 379–392.

  • Darbinian N, Gallia GL, King J, Del Valle L, Johnson EM and Khalili K . (2001). J. Cell. Physiol., 189, 334–340.

  • Del Valle L, Gordon J, Ferrante P and Khalili K . (2001a). Human Polyomaviruses: Molecular and Clinical Perspectives. Stoner GL, Khalili K. (eds). John Wiley & Sons, Inc.: New York, pp. 409–430.

    Book  Google Scholar 

  • Del Valle L, Gordon J, Assimakopoulou M, Enam S, Geddes JF, Varakis J, Katsetos CD, Croul S and Khalili K . (2001b). Cancer Res., 61, 4287–4293.

  • Del Valle L, Enam S, Lassak A, Wang J-Y, Croul S, Khalili K and Reiss K . (2002a). Clin. Cancer Res., 8, 1822–1830.

  • Del Valle L, Wang JY, Lassak A, Peruzzi F, Croul S, Khalili K and Reiss K . (2002b). J. Neurovirol., 8 (Suppl. 2), 138–147.

  • Del Valle L, Gordon J, Enam S, Delbue S, Croul S, Abraham S, Radhakrishnan S, Assimakoupoulou M, Katsetos CD and Khalili K . (2002c). J. Natl. Cancer Inst., 94, 267–273.

  • Eberhart CG, Tihan T and Burger PC . (2000). J. Neuropathol. Exp. Neural., 59, 333–337.

  • Enam S, Del Valle L, Lara C, Gan DD, Ortiz-Hidalgo C, Palazzo JP and Khalili K . (2002). Cancer Res., 62, 7093–7101.

  • Fareed GC, Takemoto KK and Gimbrone Jr MA . (1978). Microbiology, Schlessinger D (ed). American Society for Microbiology: Washington, DC, pp. 427–431.

    Google Scholar 

  • Franks RR, Rencic A, Gordon J, Zoltick PW, Curtis M, Knobler RL and Khalili K . (1996). Oncogene, 12, 2573–2578.

  • Frisque RJ and White III FA . (1992). Molecular Neurovirology. Roos RP. (ed). Humana Press: Totowa, NJ, pp. 25–158.

    Book  Google Scholar 

  • Frisque RJ, Rifkin DB and Walker DL . (1980). J. Virol., 35, 265–269.

  • Gallia GL, Gordon J and Khalili K . (1998a). J. Neurovirol., 4, 175–181.

  • Gallia GL, Safak M and Khalili K . (1998b). J. Biol. Chem., 273, 32662–32669.

  • Gan DD, Reiss K, Gorrill T, Del Valle L, Croul S, Giordano A, Fishman P and Khalili K . (2001). Oncogene, 20, 4864–4870.

  • Gao ZH, Seeling JM, Hill V, Yochum A and Virshup DM . (2002). Proc. Natl. Acad. Sci. USA, 99, 1182–1187.

  • Gordon J, Del Valle L, Otte J and Khalili K . (2000). Oncogene, 19, 4840–4846.

  • Haggerty S, Walker DL and Frisque RJ . (1989). J. Virol., 63, 2180–2190.

  • He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, Morin PJ, Vogelstein B and Kinzler KW . (1998). Science, 281, 1509–1512.

  • Howard CM, Claudio PP, Gallia GL, Gordon J, Giordano GG, Hauck WW, Khalili K and Giordano A . (1998). J. Natl. Cancer. Inst., 90, 1451–1460.

  • Kang S and Folk WR . (1992). Virology, 191, 754–764.

  • Khalili K, Brady J, Papas J, Spence S, Sadofsky M and Khoury G . (1988). Proc. Natl. Acad. Sci. USA, 85, 354–358.

  • Krynska B, Del Valle L, Croul S, Gordon J, Katsetos K, Carbone M, Giordano A and Khalili K . (1999a). Proc. Natl. Acad. Sci. USA, 96, 11519–11524.

  • Krynska B, Otte J, Franks R, Khalili K and Croul S . (1999b). Oncogene, 18, 39–46.

  • Krynska B, Del Valle L, Gordon J, Otte J, Croul S and Khalili K . (2000). Virology, 274, 65–74.

  • Lassak A, Del Valle L, Peruzzi F, Wang JY, Croul S, Khalili K and Reiss K . (2002). J. Biol. Chem., 277, 17231–17238.

  • London WT, Houff SA, McKeever PE, Wallen WC, Sever JL, Padgett BL and Walker DL . (1983). Prog. Clin. Biol. Res., 105, 227–237.

  • Major EO, Amemiya K, Tornatore CS, Houff SA and Berger JR . (1992). Clin. Microbiol. Rev., 5, 49–73.

  • Monaco MC, Atwood WJ, Gravell M, Tornatore CS and Major EO . (1996). J. Virol., 70, 7004–7012.

  • Morin PJ . (1999). BioEssays, 21, 1021–1030.

  • Ohsumi S, Motoi M and Ogawa K . (1986). Acta Pathol. Jpn., 36, 815–825.

  • Patti R, Reddy CD, Geoerger B, Grotzer MA, Raghunath M, Sutton LN and Phillips PC . (2000). Int. J. Oncol., 16, 577–584.

  • Pipas JM . (1992). J. Virol., 66, 3979–3985.

  • Polakis P . (2000). Genes Dev., 14, 1837–1851.

  • Prins C and Frisque RJ . (2001). J. Neurovirol., 7, 250–264.

  • Raj G, Gordon J, Logan TJ, Hall D, Chang C-F, Sala A, De Luca A, Giordano A and Khalili K . (1995). Int. J. Oncol., 7, 801–808.

  • Reiss K . (2002). Exp. Opin. Ther. Targets, 6, 539–544.

  • Resnick J and Shenk T . (1986). J. Virol., 60, 1098–1106.

  • Riccardiello L, Chang DK, Laghi L, Goel A, Chang CL and Boland R . (2001). J. Virol., 75, 1996–2001.

  • Ricciardiello L, Laghi L, Ramamirtham P, Chang CL, Chang DK, Randolph AE and Boland CR . (2000). Gastroenterology, 119, 1228–1235.

  • Richardson Jr EP . (1961). N. Engl. J. Med., 265, 815–823.

  • Safak M, Gallia GL, Ansari SA and Khalili K . (1999). J. Virol., 73, 10146–10157.

  • Safak M, Barrucco R, Darbinyan A and Khalili K . (2001). J. Virol., 75, 1476–1486.

  • Sheaff RJ, Groudine M, Gordon M, Roberts JM and Clurman BE . (1997). Genes Dev., 11, 1464–1478.

  • Shintaku M, Matsumoto R, Sawa H and Nagashima K . (2000). J. Neuropathol. Exp. Neurol., 59, 921–929.

  • Shtutman M, Zhurinsky J, Simcha I, Albanese C, D'Amico M, Pestell R and Ben-Ze'ev A . (1999). Proc. Natl. Acad. Sci. USA, 96, 5522–5527.

  • Sima AAF, Finkelstein SD and McLachlan DR . (1983). Ann. Neurol., 14, 183–188.

  • Small JA, Khoury G, Jay G, Howley PM and Scangos GA . (1986a). Proc. Natl. Acad. Sci. USA, 83, 8288–8292.

  • Small JA, Scangos GA, Cork L, Jay G and Khoury G . (1986b). Cell, 46, 13–18.

  • Sontag E, Fedorov S, Kamibayashi C, Robbins D, Cobb M and Mumby M . (1993). Cell, 75, 887–897.

  • Sullivan CS, Tremblay JD, Fewell SW, Lewis JA, Brodsky JL and Pipas JM . (2000). Mol. Cell. Biol., 20, 5749–5757.

  • Tu X, Batta P, Innocent N, Prisco M, Casaburi I, Belletti B and Baserga R . (2002). J. Biol. Chem., 277, 44357–44365.

  • Varakis J, Zu Rhein GM, Padgett BL and Walker DL . (1978). Cancer Res., 36, 1718–1722.

  • Walker DL and Padgett BL . (1978). Microbiology, Schlessinger D (ed). American Society for Microbiology: Washington, DC, pp. 432–434.

    Google Scholar 

  • Walker DL, Padgett BL, ZuRhein GM, Albert AE and Marsh RF . (1973). Science, 181, 674–676.

  • Wang JY, Del Valle L, Gordon J, Rubini M, Croul S, Peruzzi F, Khalili K and Reiss K . (2001). Oncogene, 20, 3857–3868.

  • Wheat WH, Roesler WJ and Klemm DJ . (1994). Mol. Cell. Biol., 14, 5881–5890.

  • Zerfass-Thome K, Schulze A, Zwerschke W, Vogt B, Helin K, Bartek J, Henglein B and Jansen-Durr P . (1997). Mol. Cell. Biol., 17, 407–415.

  • Zu Rhein GM and Varakis JN . (1979). Perinatal Carcinogenesis: National Cancer Institute Monograph, Vol. 51. Rice JM (ed). National Cancer Institute: Bethesda, MD, pp. 205–221.

    Google Scholar 

Download references

Acknowledgements

We express our appreciation to past and present members of the Center for Neurovirology and Cancer Biology for their contribution, and to Cynthia Schriver for editorial assistance. This work was made possible by grants awarded by NIH to KR and KK.

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  1. Center for Neurovirology and Cancer Biology, Temple University, Philadelphia, 19122, PA, USA

    Krzysztof Reiss & Kamel Khalili

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  1. Krzysztof Reiss
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  2. Kamel Khalili
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Correspondence to Kamel Khalili.

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Reiss, K., Khalili, K. Viruses and cancer: lessons from the human polyomavirus, JCV. Oncogene 22, 6517–6523 (2003). https://doi.org/10.1038/sj.onc.1206959

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