Oncogene

FIGURE 2

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Fusion of an AF4-related gene, LAF4, to MLL in childhood acute lymphoblastic leukemia with t(2;11)(q11;q23)

Mitsuteru Hiwatari, Tomohiko Taki, Takeshi Taketani, Masafumi Taniwaki, Kenichi Sugita, Mayuko Okuya, Mitsuoki Eguchi, Kohmei Ida and Yasuhide Hayashi

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Figure 2.

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(a) Different fusion transcripts of MLL-LAF4 are schematically depicted. The gray/dotted boxes denote predicted MLL exons and the white boxes represent predicted LAF4 exons. ALL-5S and LAF4-2AS indicate the primers used for RT–PCR. (b) Schematic illustration of LAF4, AF4, and AF5q31 proteins. Arrows indicate the fusion points with MLL. The horizontal scale shows the amino-acid positions based on the LAF4 protein sequence

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