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12 September 2002, Volume 21, Number 41

Table of Contents

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Original Papers
Sequential activation and inactivation of G2 checkpoints for selective killing of p53-deficient cells by microtubule-active drugs FREE
Mikhail V Blagosklonny
Abstract  |  Full Article  |  PDF 6249
Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways FREE
Wenle Xia, Robert J Mullin, Barry R Keith, Lei-Hua Liu, Hong Ma, David W Rusnak, Gary Owens, Krystal J Alligood & Neil L Spector
Abstract  |  Full Article  |  PDF 6255
FR901228, an inhibitor of histone deacetylases, increases the cellular responsiveness to IL-6 type cytokines by enhancing the expression of receptor proteins FREE
Frédéric Blanchard, Erin Kinzie, Yanping Wang, Laurence Duplomb, Anne Godard, William A Held, Bonnie B Asch & Heinz Baumann
Abstract  |  Full Article  |  PDF 6264
Role for the double-stranded RNA activated protein kinase PKR in E2F-1-induced apoptosis FREE
Stephan A Vorburger, Abujiang Pataer, Kazumi Yoshida, Glen N Barber, Weiya Xia, Paul Chiao, Lee M Ellis, Mien-Chie Hung, Stephen G Swisher & Kelly K Hunt
Abstract  |  Full Article  |  PDF 6278
Gene expression in epithelial ovarian carcinoma FREE
Daniela Matei, Thomas G Graeber, Rae Lynn Baldwin, Beth Y Karlan, Jianyu Rao & David D Chang
Abstract  |  Full Article  |  PDF 6289
Heterozygosity for p53 promotes microsatellite instability and tumorigenesis on a Msh2 deficient background FREE
Neil J Toft, Lucy J Curtis, Owen J Sansom, Andrea L Leitch, Andrew H Wyllie, Hein te Riele, Mark J Arends & Alan R Clarke
Abstract  |  Full Article  |  PDF 6299
Sck is expressed in endothelial cells and participates in vascular endothelial growth factor-induced signaling FREE
Kirsty E Ratcliffe, Qi Tao, Burju Yavuz, Konstantin V Stoletov, Simone C Spring & Bruce I Terman
Abstract  |  Full Article  |  PDF 6307
Thioredoxin reductase regulates AP-1 activity as well as thioredoxin nuclear localization via active cysteines in response to ionizing radiation FREE
Shervin Karimpour, Junyang Lou, Lilie L Lin, Luis M Rene, Lucio Lagunas, Xinrong Ma, Sreenivasu Karra, C Matthew Bradbury, Stephanie Markovina, Prabhat C Goswami, Douglas R Spitz, Kiichi Hirota, Dhananjaya V Kalvakolanu, Junji Yodoi & David Gius
Abstract  |  Full Article  |  PDF 6317
Raf-1-induced growth arrest in human mammary epithelial cells is p16-independent and is overcome in immortal cells during conversion FREE
Catherine L Olsen, Betty Gardie, Paul Yaswen & Martha R Stampfer
Abstract  |  Full Article  |  PDF 6328
The ubiquitous and tissue specific promoters of the human SRC gene are repressed by inhibitors of histone deacetylases FREE
Calley L Kostyniuk, Scott M Dehm, Danielle Batten & Keith Bonham
Abstract  |  Full Article  |  PDF 6340
Inhibition by Wnt-1 or Wnt-3a of nerve growth factor-induced differentiation of PC12 cells is reversed by bisindolylmaleimide-I but not by several other PKC inhibitors FREE
Alice H Chou & Bruce D Howard
Abstract  |  Full Article  |  PDF 6348
Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells FREE
Edward Im, Friederike C von Lintig, Jeffrey Chen, Shunhui Zhuang, Wansong Qui, Shoaib Chowdhury, Paul F Worley, Gerry R Boss & Renate B Pilz
Abstract  |  Full Article  |  PDF 6356
Serial analysis of gene expression in normal p53 null mammary epithelium FREE
C Marcelo Aldaz, Yuhui Hu, Rachael Daniel, Sally Gaddis, Frances Kittrell & Daniel Medina
Abstract  |  Full Article  |  PDF 6366
Short Reports
Ku affects the ATM-dependent S phase checkpoint following ionizing radiation FREE
Xiang-Yang Zhou, Xiang Wang, Hongyan Wang, David J Chen, Gloria C Li, George Iliakis & Ya Wang
Abstract  |  Full Article  |  PDF 6377
Targeted expression of the receptor tyrosine kinase RON in distal lung epithelial cells results in multiple tumor formation: oncogenic potential of RON in vivo FREE
Yi-Qing Chen, Yong-Qing Zhou, James H Fisher & Ming-Hai Wang
Abstract  |  Full Article  |  PDF 6382
Oncogenomics
Isolation of HELAD1, a novel human helicase gene up-regulated in colorectal carcinomas FREE
Hideyuki Ishiguro, Takashi Shimokawa, Tatsuhiko Tsunoda, Toshihiro Tanaka, Yoshitaka Fujii, Yusuke Nakamura & Yoichi Furukawa
Abstract  |  Full Article  |  PDF 6387
Characterization of a 500 kb region on 17q25 and the exclusion of candidate genes as the familial Tylosis Oesophageal Cancer (TOC) locus FREE
Janet M Risk, Kathryn E Evans, Joanne Jones, Joanne E Langan, Lyn Rowbottom, Fiona E McRonald, Helen S Mills, Anthony Ellis, Joan M Shaw, Irene M Leigh, David P Kelsell & John K Field
Abstract  |  Full Article  |  PDF 6395
12 September 2002, Volume 21, Number 41
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