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Transcription factor fusions in acute leukemia: variations on a theme

Oncogene volume 21, pages 3422–3444 (2002)Cite this article

Abstract

The leukemia-associated fusion proteins share several structural or functional similarities, suggesting that they may impart a leukemic phenotype through common modes of transcriptional dysregulation. The fusion proteins generated by these translocations usually contain a DNA-binding domain, domains responsible for homo- or hetero-dimerization, and domains that interact with proteins involved in chromatin remodeling (e.g., co-repressor molecules or co-activator molecules). It is these shared features that constitute the ‘variations on the theme’ that underling the aberrant growth and differentiation that is the hallmark of acute leukemia cells.

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Acknowledgements

We thank Ms Ellie Park for her assistance in preparing this manuscript for publication. This work was supported in part by NIH RO1 grant DK 52208 (SD Nimer), and by a Leukemia and Lymphoma Society SCOR grant (SD Nimer), a Clinical Scholars Award CA09512 from the NCI and the Charles A. Dana Foundation (JM Scandura), and by the Renny Saltzman Leukemia Research Fund (SD Nimer).

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  1. Laboratory of Molecular Aspects of Hematopoiesis, Sloan-Kettering Institute Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, 10021, NY, USA

    Joseph M Scandura, Piernicola Boccuni, Jorg Cammenga & Stephen D Nimer

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Scandura, J., Boccuni, P., Cammenga, J. et al. Transcription factor fusions in acute leukemia: variations on a theme. Oncogene 21, 3422–3444 (2002). https://doi.org/10.1038/sj.onc.1205315

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