|
|
|
| 20 December 2001, Volume 20, Number 58, Pages 8299-8307 |
| Table of contents Previous Abstract Next Full text PDF |
 |
| Review |
| Emc, a negative HLH regulator with multiple functions in Drosophila development |
|
| Sonsoles Campuzano |
|
Centro de Biología Molecular Severo Ochoa, Cantoblanco, 28049 Madrid, Spain
|
|
Correspondence to: S Campuzano, Centro de Biología Molecular Severo Ochoa, Cantoblanco, 28049 Madrid, Spain. E-mail: scampuzano@cbm.uam.es
|
|
| Abstract |
| Expression and functional analyses of Emc have demonstrated that it is a prototype for a protein required for multiple processes in development. Initially characterized as a negative regulator of sensory organ development, it was later found to regulate many other developmental processes and cell proliferation. Its ability to block the function of bHLH proteins by forming heterodimers, which are ineffective in DNA binding, accounts for the role of Emc in preventing the acquisition of several cell fates which are under the control of bHLH proteins. However, while maintaining this repressive molecular mechanism, emc also appears to act as a positive regulator of differentiation. Oncogene (2001) 20, 8299-8307 |
|
| Keywords |
| Drosophila; extramacrochaetae; HLH; transcription factor; development |
|
|
|
|
|
|
| 20 December 2001, Volume 20, Number 58, Pages 8299-8307 |
| Table of contents Previous Abstract Next Full text PDF |
|
|
