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| Review |
| The regulation and function of the Id proteins in lymphocyte development |
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| Richard Rivera and Cornelis Murre |
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Division of Biology, 0366, University of California at San Diego, La Jolla, California, CA 92093, USA
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Correspondence to: R Rivera, Division of Biology, 0366, University of California at San Diego, La Jolla, California, CA 92093, USA. E-mail: r3@biomail.ucsd.edu
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| Abstract |
| Helix-loop-helix (HLH) proteins are essential factors for lymphocyte development and function. One class of HLH proteins, the E-proteins, regulate many aspects of lymphocyte maturation, survival, proliferation, and differentiation. E-proteins are negatively regulated by another class of HLH proteins known as the Id proteins. The Id proteins function as dominant negative inhibitors of E-proteins by inhibiting their ability to bind DNA. Here we discuss the function and regulation of the Id proteins in lymphocyte development. Oncogene (2001) 20, 8308-8316 |
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| Keywords |
| E-proteins; bHLH; Id |
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| 20 December 2001, Volume 20, Number 58, Pages 8308-8316 |
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