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Drosophila AP-1: lessons from an invertebrate

Oncogene volume 20, pages 2347–2364 (2001)Cite this article

Abstract

In recent years, studies in the model organism Drosophila melanogaster have contributed significant insights into the molecular and developmental biology of the AP-1 transcription factors Jun and Fos. Powerful genetic and biochemical approaches uncovered a baffling complexity and variability of the signaling connections to and from AP-1. The range of biological processes that Jun and Fos regulate in this organism is equally multi-faceted. Regulatory interactions between AP-1 and JNK, ERK, TGFβ, Notch or other signaling systems have been implicated in the control of a multitude of embryonic and adult events, including tissue closure processes, patterning of eye, gut and wing, as well as apoptosis. Here we review the information that has been gathered on Drosophila AP-1 in signal transduction and on the developmental and cellular functions controlled by AP-1-mediated signals in the fly. Lessons learned from the studies on AP-1 in Drosophila may contribute to our general understanding, beyond species boundaries, ofthis fundamental class of transcriptional regulators.

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Acknowledgements

The authors thank Lena M Staszewski for technical help, Julia Zeitlinger for contributing Figure 6, Beth Stronach for discussion and Erwin Wagner for initiating this review and for his patience with delayed contributions.

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Authors and Affiliations

  1. EMBL, Meyerhofstr. 1, Heidelberg, 69117, Germany

    Jason G Homsy & Dirk Bohmann

  2. Center for Cancer Biology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 633, Rochester, 14642, New York, NY, USA

    Jason G Homsy & Dirk Bohmann

  3. Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, 02115, Massachusetts, MA, USA

    Lutz Kockel

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Kockel, L., Homsy, J. & Bohmann, D. Drosophila AP-1: lessons from an invertebrate. Oncogene 20, 2347–2364 (2001). https://doi.org/10.1038/sj.onc.1204300

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