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| Review Article |
| Potential roles of antisense technology in cancer chemotherapy |
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| Stanley T Crooke |
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Isis Pharmaceuticals, Inc. 2292 Faraday Avenue, Carlsbad, California, CA 92008, USA
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Correspondence to: S T Crooke, Isis Pharmaceuticals, Inc. 2292 Faraday Avenue, Carlsbad, California, CA 92008, USA
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| Abstract |
| Antisense technology may play a major role in cancer chemotherapy. It is clearly a tool of exceptional value in the functionalization of genes and their validation as potential targets for cancer chemotherapy. Additionally, there is now substantial evidence that antisense drugs are safe, and a growing body of data showing activity in animal models of human disease including cancer, and suggesting efficacy in patients with cancer. In this article, I review the progress in the technology, the anticancer antisense drugs in development and potential roles that antisense technology might play. Oncogene (2000) 19, 6651-6659. |
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| Keywords |
| antisense; mechanisms of action; gene functionalization; anticancer activity |
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| 27 December 2000, Volume 19, Number 56, Pages 6651-6659 |
| Table of contents Previous Abstract Next Full text PDF |
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