Abstract
ERM, ER81 and PEA3 are three highly related transcription factors belonging to the ETS family. Together they form the PEA3 group within this family. Little data is yet available regarding the roles of these three genes during embryonic development. A prerequisite to investigations in this field is to obtain an accurate spatio-temporal expression map for the erm, er81 and pea3 genes. To this end, we have used in situ hybridization to compare their expression patterns during critical stages of murine embryogenesis. We report that all three genes are expressed in numerous developing organs coming from different embryonic tissues. The three genes appeared co-expressed in different organs but presented specific sites of expression, so that the resultant expression pattern could in fact reveal several distinct functions depending upon isolated and/or various combinations of the PEA3 member expression. These results suggest that erm, er81 and pea3 genes are differentially regulated, probably to serve important functions as cell proliferation control, tissue interaction mediator or cell differentiation, all over successive steps of the mouse organogenesis.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 50 print issues and online access
$259.00 per year
only $5.18 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
This paper is dedicated to the late Dr Marie-Pierre Laget
Rights and permissions
About this article
Cite this article
Chotteau-Lelièvre, A., Desbiens, X., Pelczar, H. et al. Differential expression patterns of the PEA3 group transcription factors through murine embryonic development. Oncogene 15, 937–952 (1997). https://doi.org/10.1038/sj.onc.1201261
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/sj.onc.1201261
Keywords
This article is cited by
-
Biological and prognostic value of ETV5 in high-grade serous ovarian cancer
Journal of Ovarian Research (2021)
-
ETV4 transcription factor and MMP13 metalloprotease are interplaying actors of breast tumorigenesis
Breast Cancer Research (2018)
-
FACS-Seq analysis of Pax3-derived cells identifies non-myogenic lineages in the embryonic forelimb
Scientific Reports (2018)
-
A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs
Nature Neuroscience (2008)
-
The 26S proteasome system degrades the ERM transcription factor and regulates its transcription-enhancing activity
Oncogene (2007)