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23 January 1997, Volume 14, Number 3, Pages 349-357
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Article
The TEL gene products: nuclear phosphoproteins with DNA binding properties
Hélène Poirel1, Cécile Oury2, Clémence Carron2, Estelle Duprez1, Yacine Laabi1, Andréas Tsapis1, Serge P Romana1, Martine Mauchauffe1, Maryvonne Le Coniat1, Roland Berger1, Jacques Ghysdael2 and Olivier A Bernard1,a

1U 301 de l'Institut National de la Santé et de la Recherche Médicale (INSERM) and SD 401 No. 301 CNRS, Institut de Génétique Moléculaire, 27 rue Juliette Dodu, 75010 Paris

2CNRS UMR 146, Institut Curie-Section de Recherche, Centre Universitaire, 91405 Orsay Cedex, France

aAuthor for correspondence

Abstract

The human TEL gene is involved in several 12p13 chromosomal abnormalities present in various human hematological malignancies, the most frequent being the t(12;21)(p13;q22), specific for childhood acute lymphoblastic leukemia. The predicted product of TEL harbours an amino acid region similar to the ETS DNA binding domain. We now report the isolation of the murine TEL cDNA and the characterization of the human TEL proteins. Human and murine TEL proteins are particularly homologous within their aminoterminal regions and their ETS domains. TEL proteins are nuclear and display specific DNA binding activity toward classical ETS binding sites. In addition, we show that TEL mRNAs initiate translation at either of the two first in-frame ATGs (codon 1 and 43) to encode 50 kDa and 57 kDa TEL proteins. In vivo, each of these primary translational products is modified by multiple phosphorylation events.

Keywords

TEL; ETS; translocation; transcription factor; leukemia; translocation

Received 1 July 1999; revised 12 September 1999; accepted 13 September 1999
23 January 1997, Volume 14, Number 3, Pages 349-357
Table of contents    Previous  Abstract  Next   Article  PDF