Intervention and Prevention
Obesity (2008) 16, 327–333; doi:10.1038/oby.2007.82
Effect of Orlistat on Eating Behavior Among Participants in a 3-year Weight Maintenance Trial
Mette Svendsen1, Aila Rissanen2, Bjørn Richelsen3, Stephan Rössner4, Fredrik Hansson5 and Serena Tonstad1
- 1Department of Preventive Cardiology, Ullevål University Hospital, Oslo, Norway
- 2Obesity Research Group, Helsinki University Central Hospital, Helsinki, Finland
- 3Department of Endocrinology and Metabolism, Aarhus University Hospital, Aarhus, Denmark
- 4Obesity University Clinic, Huddinge Hospital, Stockholm, Sweden
- 5Commitum AB, Lund, Sweden
Correspondence: Mette Svendsen, (mette.svendsen@uus.no)
Received 16 January 2007; Accepted 10 July 2007.
Abstract
Objective:
To examine the effect of orlistat on dietary restraint, disinhibition, hunger, and binge eating and to understand the relation between changes in eating behavior and weight maintenance.
Methods and Procedures:
Subjects were 306 women and men (age: 19–45 years; BMI: 37.5 
4.1 kg/m2) included in the Scandinavian Multicenter study of Obese subjects with the Metabolic Syndrome, a 3-year clinical trial of orlistat or placebo following an 8-week very low energy diet (VLED). Outcomes were changes in weight and in the Three Factor Eating Questionnaire (TFEQ) and Binge Eating Scale (BES) between screening and 17 and 33 months after randomization. As reported previously, weight gain following VLED was lower in subjects treated with orlistat than with placebo.
Results:
Compared to screening results, dietary restraint was increased and disinhibition, hunger, and binge eating were decreased in both groups. These changes were similar in both groups with the exception of the hunger score at month 33 that was reduced more in the placebo than in the orlistat group (difference between groups -1.1 (95% CI (-2.0, -0.2)) P = 0.014). In multivariate analyses, scores for restraint, disinhibition and binge eating were associated with weight loss after adjustment for BMI, gender, age, and treatment (all P 
0.002, model R 2 = 0.12–0.17).
Discussion:
Orlistat did not affect eating behavior differently in any substantial way than the placebo did in this long-term weight maintenance trial. The results indicate that increased restraint and decreased disinhibition and binge eating are important for sustained weight maintenance in obese subjects with the metabolic syndrome.
