Original Article

Obesity (2007) 15, 364–369; doi:10.1038/oby.2007.554

Impact of Surgically Induced Weight Loss on Cardiovascular Autonomic Function: One-year Follow-up*

Raelene E. Maser*,†, M. James Lenhard†,‡, Isaias Irgau§ and Gail M. Wynn§

  1. *Department of Medical Technology, University of Delaware, Newark, Delaware;
  2. †Diabetes and Metabolic Research Center, Christiana Care Health Services, Newark, Delaware;
  3. ‡Diabetes and Metabolic Diseases Center, Christiana Care Health Services, Wilmington, Delaware; and
  4. §Christiana Institute of Advanced Surgery, Newark, Delaware.

Correspondence: Raelene E. Maser Department of Medical Technology, 305F Willard Hall, Education Building, University of Delaware, Newark, DE 19716. E-mail: rmaser@udel.edu

*The costs of publication of this article were defrayed, in part, by the payment of page charges. This article must, therefore, be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Received 24 May 2006; Revised  00; Accepted 15 September 2006.

Top

Abstract

Objective:

 

To determine the impact of surgically induced weight loss on cardiovascular autonomic function in subjects with severe obesity and examine whether the effect was comparable for persons with and without diabetes.

Research Methods and Procedures:

 

Twenty-six severely obese individuals (BMI = 48 plusminus 7 kg/m2) underwent bariatric surgery (laparoscopic Roux-en-Y gastric bypass, n = 21; laparoscopic adjustable gastric banding, n = 5). Cardiovascular autonomic function (heart rate variation during deep breathing and the Valsalva maneuver) was assessed before and 6 and 12 months after surgery.

Results:

 

Twelve months after bariatric surgery, there was a 28% decrease in BMI. There was an increase in all parasympathetic indices of autonomic function (all assessment modalities, p < 0.05) with weight loss. The amount of improvement from baseline for all measures of autonomic function did not differ for those with or without diabetes.

Discussion:

 

Surgically induced weight loss 12 months after surgery has a favorable effect on cardiovascular autonomic function in severely obese individuals with and without diabetes.

Keywords:

RR variation, heart rate variation, bariatric surgery, Roux-en-Y gastric bypass, gastric banding

Extra navigation

.
ADVERTISEMENT