Original Article

Obesity (2007) 15, 286–391; doi:10.1038/oby.2007.546

Vitamin E Supplementation and Plasma 8-Isoprostane and Adiponectin in Overweight Subjects*

Wayne H. F. Sutherland1, Patrick J. Manning1, Robert J. Walker1, Sylvia A. de Jong1, Anne R. Ryalls1 and Elizabeth A. Berry1

Medicine Section, Department of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.

Correspondence: Wayne Sutherland Medicine Section, Department of Medical and Surgical Sciences, University of Otago, P.O. Box 913, Dunedin, New Zealand. E-mail: wayne.Sutherland@stonebow.otago.ac.nz

*The costs of publication of this article were defrayed, in part, by the payment of page charges. This article must, therefore, be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Received 1 March 2006; Revised  00; Accepted 22 September 2006.

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Abstract

Objective:

 

Isoprostanes are a marker of oxidant stress and atherosclerotic risk, and plasma concentrations are elevated in obesity. Adiponectin is a regulator of insulin sensitivity, and low circulating levels are associated with oxidant stress and obesity. The aim of this study was to determine the effect of vitamin E supplementation on plasma concentrations of 8-isoprostane and adiponectin in overweight/obese subjects.

Research Methods and Procedures:

 

The study was a 6-month, randomized, double-blind, placebo-controlled trial in 80 overweight subjects (60 women and 20 men, BMI >27 kg/m2). Exclusion criteria were serious illness, smoking, or taking antioxidant supplements. Participants were randomized to receive 800 IU/d natural vitamin E (n = 39) or placebo (n = 41) for 3 months with an increase in the dose to 1200 IU/d for a further 3 months. Plasma 8-isoprostane and adiponectin concentrations were measured at baseline and 3 and 6 months.

Results:

 

During 6 months of supplementation with vitamin E, plasma vitamin E concentration increased significantly (p < 0.001) by 76%, and plasma 8-isoprostane concentrations decreased significantly (-11%, p = 0.03), whereas plasma adiponectin concentrations did not change significantly.

Discussion:

 

These findings suggest that supplementation with high-dose vitamin E decreases systemic oxidative stress and 8-isoprostane concentrations in overweight/obese individuals. A decrease in plasma 8-isoprostane has the potential to reduce risk of cardiovascular disease in obesity.

Keywords:

overweight, oxidative stress, antioxidant, isoprostane, vitamin E

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