Article

Obesity Research (2004) 12, 141S–144S; doi: 10.1038/oby.2004.279

Clinical Trial Experience with Fat-Restricted vs. Carbohydrate-Restricted Weight-Loss Diets

Samuel Klein*

*Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri

Correspondence: Samuel Klein, Washington University School of Medicine, 660 S. Euclid Avenue, Box 8031, St. Louis, MO 63110-1093. E-mail: sklein@imgate.wustl.edu

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Abstract

It is unlikely that one diet is optimal for all overweight or obese persons. Both low-fat and low-carbohydrate diets have been shown to induce weight loss and reduce obesity-related comorbidities. Low-carbohydrate diets cause greater short-term (up to 6 months) weight loss than low-fat diets, but the long-term clinical safety and efficacy of these diets has not been studied.

Keywords:

clinical trial, macronutrient composition, energy density, weight loss

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