Obesity

TABLE 2

FROM:

Obesity Modulates the Association among APOE Genotype, Insulin, and Glucose in Men

Roberto Elosua, Serkalem Demissie, L. Adrienne Cupples, James B. Meigs, Peter W.F. Wilson, Ernst J. Schaefer, Dolores Corella and Jose M. Ordovas

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Table 2. Characteristics of the population and insulin and glucose levels according to APOE genotype and stratified by sex

 MenWomen
  APOE2 (n = 182) APOE3 (n = 943) APOE4 (n = 285) p APOE2 (n = 219) APOE3 (n = 979) APOE4 (n = 321) p
Age (years)* 55.4 (10.0)55.1 (10.1)55.4 (10.1)0.90055.6 (9.4)54.9 (10.1)54.5 (9.7)0.443
BMI (kg/m2)* 28.3 (4.0)28.2 (4.1)28.0 (3.8)0.62426.7 (5.5)26.6 (5.4)27.1 (5.8)0.397
Obesity (%)30.426.325.30.44021.121.323.50.680
Waist circumference (cm)* 100.1 (10.9)99.1 (10.9)98.6 (10.4)0.28987.4 (14.2)86.9 (14.2)88.1 (15.0)0.391
Abdominal obesity (%)37.932.334.00.32441.737.039.50.371
Smoking (%)22.018.819.00.60119.320.117.80.647
Alcohol (%)79.175.071.60.18366.263.867.20.485
% Energy from SF* 10.9 (2.8)10.7 (3.0)10.2 (2.7)0.05910.4 (2.7)10.4 (2.9)10.4 (2.8)0.888
Beta-blockers (%)13.211.112.60.6318.79.19.00.980
Diuretics (%)7.15.54.90.5818.78.58.70.990
Insulin (pM)* 31.7 (12.1)31.2 (12.3)33.7 (16.9)0.03129.4 (13.6)28.1 (10.1)28.9 (10.4)0.219
Glucose (mg/dL)* 103.0 (27.3)100.7 (22.8)103.5 (27.2)0.15295.0 (15.3)95.1 (15.4)96.6 (23.4)0.377

* Mean (SD).

 SF, saturated fat.

  APOE2 group includes alt epsilon2/alt epsilon2 and alt epsilon2/alt epsilon3 genotypes; APOE3 group includes alt epsilon3/alt epsilon3; and APOE4 group includes alt epsilon3/alt epsilon4 and alt epsilon4/alt epsilon4 genotypes.

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