Short Communication

Citation: Nutrition & Diabetes (2017) 7, e276; doi:10.1038/nutd.2017.22
Published online 15 May 2017

Flavonoid intake is inversely associated with obesity and C-reactive protein, a marker for inflammation, in US adults

J A Vernarelli1,2,3 and J D Lambert3

  1. 1Department of Biology, Fairfield University, Fairfield, CT, USA
  2. 2Marion Egan Peckham School of Nursing and Health Studies, Fairfield University, Fairfield, CT, USA
  3. 3Department of Food Science, The Pennsylvania State University, University Park, PA, USA

Correspondence: Dr JA Vernarelli, Department of Biology, Fairfield University, 1073 North Benson Road, Fairfield, CT 06824, USA. E-mail:

Received 6 July 2016; Revised 12 October 2016; Accepted 16 October 2016



Recent studies have demonstrated the importance of flavonoid intake and disease risk, however the association between flavonoid intake and obesity has not been evaluated in a nationally representative sample of US adults. The objective of the study was to evaluate the association between flavonoid consumption and established risk factors for obesity and obesity-related inflammation. Data from a nationally representative sample of 9551 adults who participated in the 2005–2008 National Health and Nutrition Examination Survey (NHANES) were analyzed. Flavonoid consumption was inversely associated with obesity in both men and women in multivariate models. Adults in the highest quartile of flavonoid intake had significantly lower body mass index and waist circumference than those in the lowest quartile of flavonoid intake (P<0.03 and P<0.04, respectively), and flavonoid intake was inversely related to C-reactive protein levels in women (p-trend, 0.01). These findings support a growing body of laboratory evidence that flavonoid consumption may be beneficial for disease prevention.

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