Chaperones and transcriptional regulation by nuclear receptors
Jason C. Young
& F. Ulrich Hartl
Jason C. Young and F. Ulrich Hartl are in the Department of Cellular Biochemistry, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18a, D-82152 Martinsried, Germany. uhartl@biochem.mpg.de
Molecular chaperones generally assist in the folding of proteins, and the cytoplasmic chaperone Hsp90, with its cofactors, additionally aids the activation of signaling proteins, including nuclear receptors. New evidence suggests that these chaperones also act to disassemble and down-regulate transcriptionally active nuclear receptor complexes.
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