Kelley S. Yan and Ming-Ming Zhou are in the Structural Biology Program, Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York University, One Gustave L. Levy Place, New York, New York 10029, USA. zhoum@inka.mssm.edu
The structure of TAG, a DNA repair enzyme, reveals how evolutionary changes in the sequence of a conserved scaffold may enrich the mechanistic diversity of the DNA HhH glycosylase superfamily through a unique coupling of catalysis to substrate selectivity.
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