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Nature Structural Biology  9, 636 - 637 (2002)
doi:10.1038/nsb0902-636

Retaining your identity under stress

Frederick Sachs

Frederick Sachs is in the Department of Physiology and Biophysical Sciences of the State University of New York at Buffalo, 320 Cary Hall, Buffalo, New York 14214, USA. sachs@buffalo.edu

Mechanosensitive ion channels from bacteria open like an iris, with the transmembrane helices tilting into the membrane to make a thin, wide structure with a 3 nm pore.

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RESEARCH
Open channel structure of MscL and the gating mechanism of mechanosensitive channels
Nature Article (29 Aug 2002)
Physical principles underlying the transduction of bilayer deformation forces during mechanosensitive channel gating
Nature Structural Biology Article (01 Sep 2002)
A large iris-like expansion of a mechanosensitive channel protein induced by membrane tension
Nature Structural Biology Article (01 Sep 2002)
The gating mechanism of the large mechanosensitive channel MscL
Nature Letters to Editor (08 Feb 2001)
Structural and functional differences between two homologous mechanosensitive channels of Methanococcus jannaschii
The EMBO Journal Article (17 Apr 2001)
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Nature Structural & Molecular Biology
ISSN: 1545-9993
EISSN: 1545-9985
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