A new fold on an old story: attachment of intermediate filaments to
desmosomes
Pierre A. Coulombe
Pierre A. Coulombe is in the Department of
Biological Chemistry, Johns Hopkins University School of Medicine,
Baltimore, Maryland 21205, USA.
coulombe@jhmi.edu.
Desmoplakin is a major and essential constituent of the interface
between the transmembrane glycoproteins mediating adhesion and the intermediate
filament cytoskeleton in the cell interior. The structures of two desmoplakin
domains that participate in intermediate filament binding reveal that a unique
38-amino acid repeat-containing domain shared with related proteins packs in a
novel globular fold.
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