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Nature Structural Biology  9, 496 - 497 (2002)
doi:10.1038/nsb0702-496

Cutting the leash

Dorothee Kern

Dorothee Kern is in the Department of Biochemistry, Brandeis University, Waltham, Massachusetts 02454, USA. dkern@brandeis.edu

The structural comparison of a Gag fragment comprising matrix and the N-terminal domain of capsid with mature matrix and capsid provides insight into the structural rearrangement upon viral maturation. Proteolytic cleavage of Gag triggers beta-hairpin formation in capsid.

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A conformational switch controlling HIV-1 morphogenesis
The EMBO Journal Article (04 Jan 2000)

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Open Innovation Challenges

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Nature Structural & Molecular Biology
ISSN: 1545-9993
EISSN: 1545-9985
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