Ahmad Khorchid and Mitsuhiko Ikura are in the Division of Molecular and Structural Biology, Ontario Cancer Institute, and the Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9.
The discovery of two unexpected Ca2+-binding sites in the structure of a minimal catalytic domain of -calpain reveals a new mechanism underlying the Ca2+-dependent activation of calpains.
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-calpain reveals a new mechanism underlying the Ca2+-dependent activation of calpains.
