How a rotavirus hijacks the human protein synthesis machinery
Gabriele Varani1
& Frédéric H.-T. Allain2
1
Gabriele Varani is in the Departments of Chemistry and Biochemistry, University of Washington, Seattle Washington 98102-1700, USA.
2
Frédéric H.-T. Allain is at ETH Zurich, Department of Biology, Institut fur Molekularbiologie und Biophysik, ETH Honggerberg, HPK, CH-8093 Zurich, Switzerland.
The NSP3 protein from rotaviruses recognizes a unique sequence at the 3' end of the rotaviral mRNA. By doing so, it promotes translation of viral proteins while repressing host protein synthesis. The structure of the NSP3 protein bound to a viral 3' end sequence reveals how this occurs and suggests how it might be possible to design a new class of antiviral drugs.
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