Nature Structural & Molecular Biology
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February 2002 - Vol 9 No 2
Nature Structural Biology 9 (2002)
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TonEBP is a transcription factor that regulates gene expression induced by osmotic stress in mammalian cells. The crystal structure of TonEBP (orange ribbon in glass surface) in complex with a target DNA (purple) reveals that the transcription factor binds as a dimer and completely wraps around the DNA. This binding mode retards dissociation of the complex and may be the major mechanism of TonEBP binding to DNA. See pages 90-94.
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