Molecular mimicry connects BRCA2 to Rad51 and recombinational DNA repair
Stephen C. Kowalczykowski
Stephen C. Kowalczykowski is in the Division of Biological Sciences, Sections of Microbiology and of Molecular and Cellular Biology, Center for Genetics and Development, University of California, Davis, California 95616-8665, USA. sckowalczykowski@ucdavis.edu
The crystal structure of the central region of Rad51 bound to a BRC peptide from BRCA2 shows that the BRC peptide mimics a structural motif within Rad51 and can thereby regulate assembly of the Rad51 nucleoprotein filament needed for DNA repair.
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