A (ribo) switch in the paradigms of genetic regulation
Jay R. Hesselberth
& Andrew D. Ellington
Jay R. Hesselberth and Andrew D. Ellington are in the Department of Chemistry and Biochemistry, Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas 78712, USA.
Proteins are the dogmatic workhorses of genetic regulation, able to both sense the presence of small molecules and control gene expression levels. Two recent studies have now shown that RNA molecules can also serve as the 'sensor' components of genetic regulatory circuits.
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