Nuclear coupling: RNA processing reaches back to transcription
James L. Manley
James L. Manley is in the Department of Biological Sciences, Columbia University, New York, New York 10027, USA. jlm2@columbia.edu
Considerable evidence indicates that the processes involved in synthesizing mature messenger RNA in the eukaryotic nucleus are intimately coupled to one another. RNA polymerase II plays an important role in all of these events, participating in its primary function in transcription as well as in subsequent RNA processing. Unexpectedly, recent studies indicate that RNA processing factors can reciprocate, 'reaching back' in the pathway to influence transcription.
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