 | Figure 1
Nature Structural Biology
9, 719 - 724 (2002)
Published online: 23 September 2002; | doi:10.1038/nsb848
The Sak polo-box comprises a structural domain sufficient for mitotic subcellular localizationGenie C. Leung, John W. Hudson, Anna Kozarova, Alan Davidson, James W. Dennis
& Frank Sicheri | | | | Figure 1. Structure-based sequence alignment of the Plk family polo domains.
The polo domains from Sak orthologs are shown on top, and polo domains 1 and 2 from all other Plks are shown in the middle and bottom, respectively. The secondary structure of the polo domain of Sak is indicated above the alignment. Residue numbers for the start of each amino acid sequence are shown on the left. Conserved hydrophobic core residues are green or yellow (green denotes hydrophobic residues conserved in all polo domains and yellow denotes hydrophobic residues conserved within the first or second polo domain); Asp residues, red; Asn residues, orange; Lys residues, blue; and Arg residues, turquoise. Positions are identified as conserved if >85% of residues are identical or are hydrophobic in nature. Conserved dimer interface (red arrow), pocket (filled circle) and cleft (open triangle) positions are indicated. The linker regions between polo domains 1 and 2 are outlined in purple. Species notation is as follows: m = Mus musculus, h = Homo sapiens, Dm = Drosophila melanogaster, Dr = Danio rerio, r = Rattus norvegicus, Ce = Caenorhabditis elegans, u = Hemicentrotus pulcherrimus, Tb = Trypansoma brucei and asterisk = partial EST sequences available only.
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