Véronique Albanèse and Judith Frydman are in the Department of Biological Sciences, Stanford University, Stanford, California 94305-5020 USA. jfrydman@stanford.edu
Two recent studies provide evidence for a direct interaction between the ribosomal protein L23 at the exit tunnel of the ribosome and the bacterial chaperone trigger factor, and between the eukaryotic L23 homolog and the signal recognition particle. These findings indicate that the exit site of the ribosome may physically link translation to the cytosolic components that guide nascent polypeptides to their correct fate.
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