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Designer drug, designed therapy p1
doi:10.1038/nsb0102-1
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(31K)
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| News and Views | Top |
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Disulfides out of thin air pp2 - 3
Jean-François Collet
& James C.A. Bardwell
doi:10.1038/nsb0102-2
Abstract | Full text | PDF
(203K)
See also: Article by Gross et al. |
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Lessons from a bacterial cocaine esterase pp4 - 5
William F. Bosron
& Thomas D. Hurley
doi:10.1038/nsb0102-4
Abstract | Full text | PDF
(46K)
See also: Letter by Larsen et al. |
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Hanging on to the branch pp5 - 7
Jonathan P. Staley
doi:10.1038/nsb0102-5
Abstract | Full text | PDF
(783K)
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Degrading liaisons: Siah structure revealed pp8 - 10
John C. Reed
& Kathryn R. Ely
doi:10.1038/nsb0102-8
Abstract | Full text | PDF
(875K)
See also: Article by Polekhina et al. |
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| Picture Story | Top |
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A state-of-the-Arp structure p11
Julie Hollien
doi:10.1038/nsb0102-11
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(553K)
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| Letters | Top |
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A novel mechanism of tumorigenesis involving pH-dependent destabilization of a mutant p53 tetramer pp12 - 16
Enrico L. DiGiammarino, Amanda S. Lee, Craig Cadwell, Weixing Zhang, Brian Bothner, Raul C. Ribeiro, Gerard Zambetti
& Richard W. Kriwacki
Published online: 26 November 2001 | doi:10.1038/nsb730
Abstract | Full text | PDF
(1,605K)
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Crystal structure of a bacterial cocaine esterase pp17 - 21
Nicholas A. Larsen, James M. Turner, James Stevens, Susan J. Rosser, Amrik Basran, Richard A. Lerner, Neil C. Bruce
& Ian A. Wilson
Published online: 17 December 2001 | doi:10.1038/nsb742
PDB code 1JU3 | 1JU4
Abstract | Full text | PDF
(1,459K)
See also: News and Views by Bosron & Hurley |
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Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders pp22 - 26
Claudia Binda, Paige Newton-Vinson, Frantisek Hubálek, Dale E. Edmondson
& Andrea Mattevi
Published online: 26 November 2001 | doi:10.1038/nsb732
PDB code 1GOS
Abstract | Full text | PDF
(1,677K)
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The crystal structure of spermidine synthase with a multisubstrate adduct inhibitor pp27 - 31
Sergey Korolev, Yoshihiko Ikeguchi, Tatiana Skarina, Steven Beasley, Cheryl Arrowsmith, Aled Edwards, Andrzej Joachimiak, Anthony E. Pegg
& Alexei Savchenko
Published online: 03 December 2001 | doi:10.1038/nsb737
PDB code 1INL | 1JQ3
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A unique fold of phospholipase C- mediates dimerization and interaction with G q pp32 - 36
Alex U. Singer, Gary L. Waldo, T. Kendall Harden
& John Sondek
Published online: 26 November 2001 | doi:10.1038/nsb731
PDB code 1JAD
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Phototransformation of green fluorescent protein with UV and visible light leads to decarboxylation of glutamate 222 pp37 - 41
Jasper J. van Thor, Thomas Gensch, Klaas J. Hellingwerf
& Louise N. Johnson
Published online: 10 December 2001 | doi:10.1038/nsb739
PDB code 1HCJ
Abstract | Full text | PDF
(1,080K)
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Sequence selectivity and degeneracy of a restriction endonuclease mediated by DNA intercalation pp42 - 47
Nancy C. Horton, Lydia F. Dorner
& John J. Perona
Published online: 17 December 2001 | doi:10.1038/nsb741
PDB code 1KC6
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Dramatic modulation of electron transfer in protein complexes by crosslinking pp48 - 52
Irene M. C. van Amsterdam, Marcellus Ubbink, Oliver Einsle, Albrecht Messerschmidt, Angelo Merli, Davide Cavazzini, Gian Luigi Rossi
& Gerard W. Canters
Published online: 10 December 2001 | doi:10.1038/nsb736
PDB code 1JVO | 1JVL
Abstract | Full text | PDF
(2,270K)
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Domain alternation switches B12-dependent methionine synthase to the activation conformation pp53 - 56
Vahe Bandarian, Katherine A. Pattridge, Brett W. Lennon, Donald P. Huddler, Rowena G. Matthews
& Martha L. Ludwig
Published online: 03 December 2001 | doi:10.1038/nsb738
PDB code 1K7Y | 1K98
Abstract | Full text | PDF
(1,577K)
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The antimalarial and cytotoxic drug cryptolepine intercalates into DNA at cytosine-cytosine sites pp57 - 60
John N. Lisgarten, Miquel Coll, Jose Portugal, Colin W. Wright
& Juan Aymami
Published online: 03 December 2001 | doi:10.1038/nsb729
PDB code 1K9G
Abstract | Full text | PDF
(1,171K)
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| Articles | Top |
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A new FAD-binding fold and intersubunit disulfide shuttle in the thiol oxidase Erv2p pp61 - 67
Einav Gross, Carolyn S. Sevier, Andrea Vala, Chris A. Kaiser
& Deborah Fass
Published online: 10 December 2001 | doi:10.1038/nsb740
PDB code 1JR8 | 1JRA
Abstract | Full text | PDF
(2,276K)
See also: News and Views by Collet & Bardwell |
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Siah ubiquitin ligase is structurally related to TRAF and modulates TNF- signaling pp68 - 75
Galina Polekhina, Colin M. House, Nadia Traficante, Joel P. Mackay, Frédéric Relaix, David A. Sassoon, Michael W. Parker
& David D.L. Bowtell
Published online: 17 December 2001 | doi:10.1038/nsb743
PDB code 1K2F
Abstract | Full text | PDF
(1,834K)
See also: News and Views by Reed & Ely |
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