The C-terminus of p53: the more you learn the less you know
Jinwoo Ahn
& Carol Prives
Jinwoo Ahn and Carol Prives are in the Department of Biological Sciences, Columbia University, New York, New York 10027, USA.
Correspondence should be addressed to Carol Prives clp3@columbia.edu
NMR analyses of variants of the p53 tumor suppressor protein that either contain or lack the C-terminus reveal that the C-terminus neither interacts with other regions of p53 nor has an impact on the conformation of the rest of the molecule. Nevertheless, the C-terminus is likely to be critical for regulation of p53 function.
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