Fredric S. Cohen and Grigory B. Melikyan are in the Department of Molecular Biophysics and Physiology, Rush Medical College, 1653 W. Congress Parkway, Chicago, Illinois 60612, USA.
Correspondence should be addressed to Fredric S. Cohen fcohen@rush.edu
The membrane-inserted structure of a synthetic fusion peptide of influenza virus hemagglutinin has been determined. Structures such as this will further our understanding of the roles of the fusion peptide and may provide a means to develop a systematic view for how fusion peptide mutations in hemagglutinin affect the membrane fusion process.