Paul A. Wade is in the Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA. Alan P. Wolffe was Chief Scientific Officer at Sangamo BioSciences Incorporated, Richmond, California 94804, USA.
Correspondence should be addressed to Paul A. Wade pwade@emory.edu
The solution structure of a 5-methyl CpG dinucleotide in complex with the methyl-CpG binding domain from human MBD1 has provided new insights into how dinucleotide sequences are specifically recognized. Surprisingly, the methyl groups of the symmetrically methylated CpG sequence are each recognized in a distinct manner.
