Kenneth E. Prehoda and Wendell A. Lim are in the Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 513 Parnassus Ave. San Francisco, California 94143-0450, USA.
Recent structural and cell biological studies show that the previously uncharacterized PX domain can bind both phospholipids and SH3 domains, suggesting that this module may play a critical role in coordinating membrane localization and protein complex assembly during cell signaling.
