Michael J. Rudolph and J. Peter Gergen are in the Department of Biochemistry and Cell Biology and the Centers for Structural Biology and Developmental Genetics, Stony Brook University, Stony Brook, New York 11794-5215, USA.
Recent structures of the Runx1−CBF heterodimer bound to DNA brings to six the number of characterized eukaryotic transcription factor families that use an immunoglobulin (Ig) fold to bind to DNA. Variation in the loop regions accounts for the diversity of DNA sequences recognized by Ig-fold proteins, but there are recurring themes in the interactions made by specific loop regions and how these interactions are regulated.
heterodimer bound to DNA brings to six the number of characterized eukaryotic transcription factor families that use an immunoglobulin (Ig) fold to bind to DNA. Variation in the loop regions accounts for the diversity of DNA sequences recognized by Ig-fold proteins, but there are recurring themes in the interactions made by specific loop regions and how these interactions are regulated.
