 | Figure 2
Nature Structural Biology
8, 215 - 220 (2001)
doi:10.1038/84948
Structure of human biliverdin IX reductase, an early fetal bilirubin IX producing enzymePedro José Barbosa Pereira, Sandra Macedo-Ribeiro, Antonio Párraga, Rosa Pérez-Luque, Orla Cunningham, Kevin Darcy, Timothy J. Mantle
& Miquel Coll | | | | Figure 2. Human BVR-B binds specifically to NADP.
a, Stereo view of the NADP+ cofactor binding site. Putative hydrogen bonds are shown as dotted green lines, and solvent molecules as red spheres. The atom color code is the same as in Fig. 1b. The 1.15 Å 2Fo - Fc electron density map for the cofactor, contoured at 1.5  , is shown in blue. Residues interacting with NADP+ are numbered. b, Solid surface representation of human BVR-B in complex with NADP+ showing the wide substrate binding site adjacent to the cofactor. Electrostatic surface potentials are contoured from -10 (red) to 10 (blue) kBT e-1. The cofactor carbon atoms are shown in white, phosphorous in yellow, nitrogens in blue and oxygens in red.
|
| | | |  |
|
