1
Robert M. Blumenthal is in the Department of Microbiology and Immunology, Medical College of Ohio, 3055 Arlington Avenue, Toledo, Ohio 43614-5806, USA
2
Xiaodong Cheng is in the Department of Biochemistry, Emory University School of Medicine, 1510 Clifton Road, Atlanta, Georgia 30322, USA.
The cocrystal structure of TaqI DNA methyltransferase in complex with its specific DNA substrate adds to the growing list of structurally confirmed DNA base-flipping enzymes, and provides a basis for the general mechanism of AdoMet-dependent DNA N-methylation.