Song Tan is in the Center for Gene Regulation, Department of Biochemistry & Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802-1014, USA. sxt30@psu.edu
The structure of yeast Esa1 suggests that different families of histone acetyltransferases employ similar mechanisms of substrate binding and catalysis. Deletion studies used to optimize the protein for crystallization also emphasize the importance of Esa1 function within a larger, multiprotein HAT complex.
