Measuring conformational dynamics of biomolecules by single molecule fluorescence spectroscopy
Shimon Weiss
Materials Sciences and Physical Biosciences Divisions, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.
Correspondence should be addressed to Shimon Weiss sweiss@lbl.gov
Dynamic structural changes of macromolecules undergoing biochemical reactions can be studied using novel single molecule spectroscopy tools. Recent advances in applying such distance and orientation molecular rulers to biological systems are reviewed, and future prospects and challenges are discussed.
